Glossary
HPO axis
The hypothalamic-pituitary-ovarian (HPO) axis is the feedback loop between brain and ovaries that governs the menstrual cycle. Perimenopause reflects gradual desynchronization of this axis.
Explore with Dot — 7 days free →
Educational only — Dot is not a medical provider.
Dot provides educational wellness information, community and supportive conversation — not medical advice, diagnosis, or treatment. Clinical care is available separately through Kindr Care. If you are in crisis, call or text 988.